Malawi-born Wisten, who was a defender, joined City’s elite youth squads in 2016. The club confirmed his death in a statement posted on Twitter on Sunday.
Tributes to the teenager have been paid by City’s first-team players, with Raheem Sterling and Sergio Aguero paying their respects on social media.
The cause of Wisten’s death is unknown at this stage.
A GoFundMe page has been set up to support his family. Over $10,000 has already been raised.
The page description in part reads: “The most beautiful soul who was loved by many. Everyone who knew Jez would know that he had a smile that would light up the room.”
Rest in peace, Jeremy