Clashes between these two sides are etched into the history of the Premier League.
But with both teams slipping in recent years the fixture may have lost some of its title race importance but none of its edge.
United responded to their 6-1 defeat to Tottenham with some impressive form and head into this one on the back of a four-game unbeaten run.
Ole Gunnar Solskjaer’s side beat RB Salzburg 5-0 in midweek and the Norwegian is only expected to make limited changes.
Bruno Fernandes and Marcus Rashford should come back in with Donny van de Beek and Anthony Martial dropping out.
Arsenal have lost their last two in the league going into this one and Mikel Arteta is expected to ring the changes.
A thigh injury picked up against Dundalk in midweek looks set to rule out David Luiz with Shokdran Mustafi set to fill in.
Whilst Nicolas Pepe also looks set to start for the Spaniard after he netted a spectacular goal against the Irish club in midweek, with Eddie Nketiah and Willian also pushing for a return.
Kick off is set for 4.30pm tomorrow at Old Trafford.