The sides share a very even record in the Premier League head-to-head, with 2 wins apiece.
Last season though it was The Blades who came out on top, completing a league double over the Eagles, winning both games 1-0.
There are no fresh injury concerns for Roy Hodgson’s side after their 1-1 draw with Leicester in midweek.
Sheffield United boss Chris Wilder though is keeping his fingers crossed for the results from the latest round of coronavirus testing.
United’s clash with Burnley went ahead on Tuesday despite two players and several members of staff testing positive for Covid-19.
The club’s players underwent more testing on Thursday and, although no-one else has shown symptoms, Wilder admitted he would not be surprised if Saturday’s match against Crystal Palace is not able to go ahead.
If it does, the game at Selhurst Park on Saturday is the Premier League’s only 3 o’clock kick off.