The Saints have won four in six heading into this one and with United without a win so far this season they will be confident of a positive result.
Ralph Hasenhuttl has confirmed he has a fully fit squad to pick from against the Blades and the Austrian is only likely to make limited changes.
Star man Danny Ings netted the winner off the bench at Brighton last weekend and he looks certain to replace Moussa Djenepo in the starting XI.
Blades boss Chris Wilder has confirmed Enda Stevens and Lys Mousset will be fit to return for him with
Max Lowe and John Lundstrum set to drop down to the bench.
Kick Off on the south coast is set for 12pm at the St.Mary’s Stadium