Mourinho has promised big changes to his team following that loss in Belgium with up to six new faces in line to start against the Seagulls.
Toby Alderweireld and Matt Doherty are certain to return in defence with Tanguy Ndombele and Pierre-Emile Hojbjerg also pushing for a starting place.
Harry Kane and Son Heung-min started on the bench against Antwerp and Spurs’ in form duo will be looking to continue their impressive recent form.
Brighton on the other hand are wildly out of form with Graham Potter’s side without a win in their last five matches.
And Potter has no new updates on the injury front with Alireza Jahanbaksh and Davy Propper still sidelined and skipper Lewis Dunk still suspended.
Kick off is a late one tomorrow night with a 7.15pm start at the Tottenham Hotspur Stadium.