Skipper Jack O’Connell should be fit to start, but David McGoldrick, Lys Mousset and Sander Berge are all doubtful.
Summer signing Aaron Ramsdale comes straight into the side as first choice keeper, with fellow new faces Jaydon Bogle and Ethan Ampadu also in line for their debuts.
Wolves’ attempts to turn the club into little Portugal have continued this summer with Nuno Santo bringing in Vitinha and club record signing Fabio Silva.
Santo is expected to resist the urge to throw 19-year old Silva straight into the team, but Vitinha could replace the injured Adama Traore.
Jonny Castro is out until the new year with a knee problem, with Santo set to bring in veteran defender Fernando Marcal to face the Blades.
Kick off is 6pm sharp tomorrow night at Bramall Lane.