Defeats to Liverpool and Leicester have forced Spurs out of the Top Four in recent weeks with Nuno Santo’s Wolves winning just once this month.
Mourinho rang the changes for the midweek cup win over Stoke and the Portuguese boss is likely to recall most of his big hitters.
Toby Alderweireld, Sergio Reguilon and Son Heung-min were all rested against Michael O’Neill’s team and should be fresh to return at Molineux.
Defeat to Burnley in midweek will have raised some selection problems for Santo to mull over and he will look to overhaul his starting side.
Willy Boly and Fernando Marcal should come back to stiffen up the defence with Adama Traore and Fabio Silva set to add some greater attacking power.
Kick Off in this one is at 8pm at Molineux.