Pep Guardiola’s side showed their steel to get past Real Madrid in the last 16, but City now face the pressure of being strong favourites.
The Spaniard has developed a reputation for over thinking in big games at City, but he is likely to make only minimum changes in Lisbon.
Fernandinho is expected to continue to deputise at centre back, with Bernardo Silva potentially replacing Phil Foden in midfield.
Sergio Aguero is still out following knee surgery, meaning the hero of the last 16, Gabriel Jesus, will once again lead the line.
For Lyon, the pressure is firmly off, after they dumped out a very upset Cristiano Ronaldo and Juventus in the last round.
Rudi Garcia’s side will certainly be no pushover for City in Portugal, with exciting midfield axis of Houssem Aouar and Maxence Caqueret set to be a real test.
Up top former Manchester United star Memphis Depay will look to cause a few problems, and Garcia is also set to recall top scorer Moussa Dembele after he was rested against Juve.
THAT’S YOUR CITY LATEST NEWS, CHECK BACK IN TOMORROW FOR MORE WITH THE SPORT SOCIAL