Dean Smith’s side were granted an extra week of preparation and he’s expected to field all three of his summer signings against the Blades.
Club record transfer Ollie Watkins should lead the line at Villa Park, with Emiliano Martinez and Matty Cash also set for their league debuts.
Smith is also expected to recall Douglas Luiz and Conor Hourihane after they were given a rest for the midweek cup win at Burton.
For the Blades, they started the new campaign with a defeat, as Chris Wilder’s side lost 2-0 at home to Wolves.
Wilder has no new injuries to contend with following that game, but he is expected to make some changes.
Sander Berge and David McGoldrick both made an impact off the bench against Wolves and the pair could come in from the start in this one.
And it will be all eyes on the West Midlands tomorrow night, with a 6pm kick off at Villa Park.