The Three Lions kicked off November’s triple-header with a 3-0 friendly win against the Republic of Ireland on Thursday thanks to goals from Harry Maguire, Jadon Sancho and Dominic Calvert-Lewin.
It was as smooth an evening as England could have hoped for, but Southgate will be without suspended Maguire in Belgium on Sunday and impressive Reece James for both remaining Nations League games.
Wolves defender Coady and Manchester United forward Rashford have also been ruled out of the upcoming matches, whittling the Three Lions’ options down even further.
In a statement, the Football Association said: “Conor Coady and Marcus Rashford will miss England’s remaining November internationals.
“Coady has been forced to self-isolate having discovered he had inadvertently come into contact with somebody prior to camp who has tested positive for Covid-19 via an NHS Test and Trace alert.
“Meanwhile, Rashford’s arrival into camp had initially been delayed to allow for further assessment on an injury sustained last weekend but the Manchester United forward will now not meet up.”
England boss Gareth Southgate said:
“To lose both [Rashford and Coady] is disappointing.”
“We had some doubts about Marcus following the weekend, we hoped he might progress but it hasn’t happened.”