Blades boss Chris Wilder will be disappointed the clash is a dead rubber, as his side stayed in the running for a European place for the bulk of the season.
European football would’ve been a fitting end to an impressive top-flight return, but unfortunately, the Blades haven fallen short.
For Southampton, this season could have been drastically different following a dismal start to the season form, highlighted by a 9-0 defeat at home to Leicester.
Home form has been an issue for Saints, but they’ve had no such problems on the road, with only Liverpool and Manchester City picking up more away points.
Sheffield United are at full strength this weekend, with Luke Freeman and Ben Osborn expected shake off knocks
Saints boss Ralph Hasenhuttl is without Moussa Djenepo and Soufiane Boufal through injury.
Jan Bednarek and Nathan Tella are rated 50-50 to play against the Blades, with Jack Stephens and Michael Obafemi set to start.
Southampton v Sheffield United at St Mary’s is a 4pm kick off on Sunday, July 26.