The Clarets are yet to win in the Premier League this season and Sean Dyche is battling against a constant injury crisis.
Key trio Ben Mee, Jack Cork and Phil Bardsley all remain sidelined through injury but Matt Lowton and Erik Pieters could make the squad.
Spurs have been one of the Premier League’s most exciting sides in recent weeks but Mourinho will be unhappy with their defensive record.
His side surrendered a three-goal lead against West Ham last weekend and the Portuguese boss is set to make changes.
Eric Dier will come into the side if he passes a late fitness test and Gareth Bale looks certain to make his first Spurs start since 2013.
And it’s set for a late night in Lancashire with an 8pm kick off at Turf Moor.