The Gunners have won just once since the start of October in Premier League action and Mikel Arteta is certain to rotate his options.
Nicolas Pepe misses out through suspension, with Alexandre Lacazette set to return to the starting team as his replacement.
Bukayo Saka and Willian are also back in full training and should start, but Thomas Partey and David Luiz are expected to miss out.
For the visitors, Santo and his players are also stuck in a rut, with one win in four in the league.
But the Portuguese boss is set to stick to his guns in North London, with skipper Conor Coady the only change to his side, replacing Matt Kilman in defence.
And it’s all set for a 7.15 kick off on Sunday night at the Emirates Stadium.