Brighton and Hove Albion host reigning champions Liverpool at the Amex Stadium in Saturday’s lunchtime Premier League kick off.
Visitors Liverpool suffered a rare defeat at Anfield in the Champions League midweek losing 0-2 to Italian side Atalanta.
Jurgen Klopp made five changes for the game which represented the Reds’ first loss at home in the group stages of the competition for six seasons.
In fact, it was Liverpool’s first defeat in 90 minutes at home since they lost to Chelsea in 2018.
But it is a trip to the South Coast on the agenda this weekend, with the possibility of ending the weekend top of the Premier League.
Currently second, victory for Liverpool over Brighton and dropped points for leaders Spurs in a tough game at Chelsea will put the Reds top of the pile.
The ambition for 16th placed Brighton is different, however – after a tough run to begin the campaign, the Seagulls have struggled to pick up victories, particularly at home, with Brighton’s last 4 top flight victories coming on the road.
That includes last weekend’s win at Aston Villa, which was a welcome three points for Brighton to give them a 4 point cushion over 17th placed Burnley and a 5 point gap to the relegation zone.
An unlikely win over Liverpool could see Brighton level with Manchester City in the top flight standings.
And Graham Potter will no doubt be aware of the Champions’ sick list, with a number of first team stars out injured.
Defenders Virgil van Dijk and Joe Gomez remain long-term absentees, with midfielder Fabinho and injury-prone Joel Matip likely to be considered across the back line.
Trent Alexander-Arnold remains out with a calf problem, as do Alex Oxlade-Chamberlain and Thiago Alcantara with knee issues.
In midfield, Jordan Henderson and Naby Keita are major doubts, meaning Klopp is almost certain to call upon fringe or U23 players to fill the gaps. Xherdan Shaqiri will also be missing.
Brighton have a busy treatment room too, although Adam Lallana and Alexis Mac Allister are likely to be put through late fitness tests.
Impressive youngster Tariq Lamptey is suspended after a red card last time out against Aston Villa, but Davy Propper and Leandro Trossard could return to the fold after bouts of sickness and muscle issues respectively.
Brighton v Liverpool is a 1230 kick off on Saturday 28 November.