Paul Pogba, Donny Van De Beek and David De Gea are in contention to return for Manchester United, but Edinson Cavani and Anthony Martial will be absent against AC Milan in the Europa League.
Pogba, who has not featured since February 6 due to a thigh complaint, is in the travelling squad along with Van De Beek, while De Gea is back from paternity leave.
Cavani was named in the initial 21-man group, but Ole Gunnar Solskjaer has since confirmed he will not travel after having a negative reaction in training on Wednesday.
Martial is out of the last-16 second leg through injury, while Eric Bailly, Juan Mata and Phil Jones are also absent.
Shola Shoretire has stayed at home in order to play for the under-23s.
Manchester United travel to the San Siro with the tie finely poised at 1-1 on aggregate.
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